Dietary considerations Given that vitamin D 3 is an immunoregulating hormone and can be considered safe when supplementing it together with K 2 , Table 1 provides a rough guideline on how to raise vitamin D levels to desired values.
Conclusions Recent COVIDrelated data evaluation showed indications that a high 25 OH D blood serum level might have an impact on the mortality rate of coronavirus patients. Conflict of interests The author declares that they have no competing interests in this section. Ethics approval and consent to participate Not applicable.
Consent of publication Not applicable. Availability of data and materials Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Funding Not applicable. I wrote everything.
References Ali N. J Infect Public Health. In press. A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers. Mult Scler. Vitamin D and the immune system. J Investig Med. Aliment Pharmacol Ther. In: Reichrath J. Sunlight, vitamin D and skin cancer, advances in experimental medicine and biology. Springer; New York, NY: Eur J Immunol.
Immunol Lett. Vitamin D: a micronutrient regulating genes. Curr Pharm Des. Clin Exp Immunol. J Crit Care. Preprints; In preparation. J Personal Med. Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. Eur Rev Med Pharmacol Sci.
Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. Vitamin D deficiency: a single centre analysis of patients from countries. J Steroid Biochem Mol Biol. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.
Am J Clin Nutr. Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes Obes. Activation of CB1R promotes lipopolysaccharide-induced IL secretion by monocytic myeloid-derived suppressive cells and reduces acute inflammation and organ injury.
J Immunol Author Choice. Vitamin D status in healthy black African adults at a tertiary hospital in Nairobi, Kenya: a cross sectional study. BMC Endocr Disord. Vitamin D and the liver—correlation or cause? Vitamin D deficiency and risk of cardiovascular diseases: a narrative review. Clin Hypertens. Dig Dis Sci. Br J Nutr. Daniel Mann is a 27 year old man who has deferred his life in order to care for his mother after an accident left her a partial invalid. He is working a job he hates and is overqualified for just for the benefits.
Daniel brought down a company and wants to make it up to the other employees by getting them jobs but he ends up in a bad situation because he cannot seem to read women. In North Korea a virus has been unleashed in the population by men trying to make money inside a repressive country. Jero is a smuggler who gets tainted beef which he takes to his brother-in-law to butcher for sale. He along with several others are infected by the mucus and blood of the cows. Because of the close confines they live in the virus finds a lot of hosts in a short period of time as they go about their normal business.
There is political posturing, medical issues, military intrigue, not to mention lots of spies from all sides. South Korea is caught unaware because they just want things to calm down on both sides. This definitely makes you think. Jun 02, David Brown rated it really liked it Shelves: biological-thriller. I received an advanced reader copy of this book in exchange for an honest review. I'm a fan of biothrillers. You know, the kinds of stories that move along quickly but slow down just enough for a solid dose of science--in this case, molecular biology.
In that regard, The K2 Virus doesn't disappoint. From beginning to end, Rhine delivers well researched possibilities as the story embarks on the near-future likelihood of the next big contagion. The book is aptly titled. This is a contagion story, an I received an advanced reader copy of this book in exchange for an honest review. This is a contagion story, and the virus is front and center. The main characters are pitted against the virus as they either fight to survive or overcome it.
This tension and momentum drives the story forward at a good pace. Rhine does a nice job with the character development as well. Daniel, the main protagonist is a very believable research scientist and programmer whose family emigrated from South Korea before his birth. He mixes the appropriate amount of Western and Eastern cultures while succeeding at being quirky and sometimes naive without becoming a stereotype.
One of my pet peeves is smart characters who inexplicably do stupid things in order to move along a blundering plot. Yes, smart people do stupid things. The K2 Virus also incorporates clear knowledge of Korea and current events. I found myself being tripped up by the narrative in dozen different places. Nothing major, but it required me to slow down and come out of the story before finding my way.
I'm a slow reader, reluctant to miss anything. So when something doesn't click, I have a hard time moving on without going back over the sticky spot a few times.
Lastly, I found the omniscient third-person POV frustrating in its inconsistency. At times, the POV was very intimate with a particular character and less omniscient. For instance, the narrator wouldn't mention how or if the virus was spreading if the character didn't know. Then at other times, the POV was completely omniscient, passing along contagion information to the reader in a detached manner ie. Other than those two things, this story is a clear 4 star. I enjoyed reading it and would easily recommend it to others.
The adult themes remained well clear of anything raunchy or offensive in my opinion. Overall, an enjoyable read that had enough allure to pull me away from other things I could have been reading and keep me coming back through to the end.
Sep 14, Julie rated it liked it Shelves: book-in-exchange-for-review , thriller. This is the first book I've read by Scott Rhine and the first medical thriller that I've read in forever.
I used to read a lot of books by Michael Palmer but it's been a good while since I've picked one up. Anyway, this one is along the same lines as that. The first thing that I noticed was that the author wrote this book almost as if the virus was a character.
It was VERY interesting to experience the book this way. I'm not entirely sure why I feel like this Anyway, I liked it. It gave the book a different spin. Now, I have absolutely no clue if this is what Rhine intended Even if I just imagined it. I enjoyed how intricately this book was written. I completely believed that everything was absolutely how things in the pharmaceutical industry works.
Again, no idea if this is true but the author made it so believable that it brought a scary realness to the plot. Little side note: I really got a kick out of seeing an electron microscope within the story Like I said, the story is very intricate.
It's a smart read, very detailed and not one that you can just blow through in an afternoon. And you're not intended to. The K2 Virus is very thought provoking because of the details that the author has put onto the pages.
But because of this, I found that it reads very dry and detached. That's not necessarily a bad thing for all readers I personally didn't enjoy it because I had a hard time really getting to know the characters. I didn't feel any connection to them. Just too far removed from the characters for my taste. You know how you love some books where the plot is lacking but the characters are great? Well, on the other side of the spectrum, there are books that put the plot first and the characters take a back seat.
Nothing wrong with that, just a different writing style. I like my books to have the characters be the star of the show. That's the only reason this book received only three stars from me. Otherwise, it's beautifully written and something I know a lot of people are going to really enjoy read this. Jul 30, Chessy The Cat rated it it was amazing. Daniel Mann should have his Ph. He feels guilty about the way he left his last job and proposes a way to merge the two companies.
As part of the goodwill team, Daniel, a biochemist, goes to Seoul to help deliver a flu vaccine to the American troops. She blames him for the failure of her forme Daniel Mann should have his Ph. She blames him for the failure of her former company. Should the vaccine work as planned the new consolidated company stock should jump significantly. Veronica Varsity Kohl is a news reporter covering the increased tensions between the North and South. Daniel met her on the plane and developed a deep crush on her.
She has asked him to be her guide, yet everywhere they go they end up in trouble. Is she really interested in him or to the places his Korean family can get her access? In the meantime, a coronavirus has leaped from sick cows in North Korea to humans. During a visit to refugees that were allowed to leave the North to the South, many of who carry the virus, Daniel becomes the face of South Korea welcoming these folks into the country.
Then things get complicated. We follow the virus from the first moment it leaps into a human or patient Zero. Every time there is a possibility of exposing the existence of the virus someone tries to redirect the investigation by killing or trying to kill a key player.
Tensions between North and South Korea go to an all-time high. Add to the mix his traditional Korean family and Daniel is like a lost puppy, not sure where to turn or what to do. When he accidentally stumbles upon the K2 virus everything in his world changes and not all of it for the good.
This was an enjoyable read. I had a hard time putting it down. The ending was slightly surprising. I received this book for free from the author for review consideration. This in no way affected my opinion of the book or the content of my review. Feb 16, David King rated it really liked it. The story revolves around a young researcher, Daniel Mann who is working with a company who are assisting the US Army in inoculating their troops in South Korea against future illness.
Before long, Daniel finds himself slap bang in the middle of a major outbreak that threatens to spill out across the world. The novel was sold to me under the Hard Science-Fiction sub-genre and I feel that this label does fit adequately.
It offers quite a detailed explanation of how a potent disease can spread from patient zero to the rest of the population and covers some of the attempts by Scientists to combat it. If I had one major complaint with the plot, then it is probably in regards to the ending which I found rather rushed and unsatisfying.
In regards to the characters, they were all well-defined and had a level of complexity that impressed me. I enjoyed finding myself being surprised by some of their actions and the various hidden motivations that were ultimately driving them. I also found the various reactions on show to be quite believable with each character showing various levels of panic, fear and denial as events unfolded.
While the patient did not die, health authorities are concerned at the number of people taking ivermectin, and warn against it for anyone else who may have COVID symptoms or has been diagnosed with the virus. Other known ivermectin side-effects range from mild to the life-threatening, including seizures and coma. Ever since researchers showed ivermectin could kill SARS-CoV-2 the virus that causes COVID in the laboratory, there has been interest in whether the drug would also work to kill the virus in the human body.
Despite this, community pharmacists have reported increased demand for ivermectin, with people seeking the drug as a possible COVID treatment. In Australia, ivermectin is approved to treat parasite infections in humans. However, as a prescription-only human medicine known as schedule 4 , you can only access ivermectin legally in Australia after approval from a doctor.
So ivermectin is currently only recommended to treat and prevent COVID when used as part of a clinical trial , where patients can be more safely selected and carefully monitored. As well as more patients presenting to pharmacies with scripts, the Therapeutic Goods Administration warns about the danger of importing ivermectin products of unknown quality, bought over the internet.
This is risky because products may not contain the stated drug, may contain dangerous contaminants or much more of the drug than thought, which may result in an overdose. Of most concern are reports from Australia and overseas of people buying and taking ivermectin products intended for animal use. People may be resorting to these types of products where they have been unable to access a script for human formulations of ivermectin.
We know very little about what the drug does to humans, and the little we do know mostly comes from its use in animals. When taken at the recommended dose, the drug is generally well tolerated. But ivermectin is known to cause mild side-effects such as diarrhoea, nausea, dizziness and sleepiness.
Less common, but serious, side-effects include severe skin rashes and effects on the nervous system causing tremor, confusion and drowsiness. In higher doses, and overdose cases, these side-effects can be more severe. These include low blood pressure, problems with balance, seizures, liver injury, and it can even induce comas. However, misinformation about ivermectin and others continues to circulate.
0コメント